October 1, 1990AJP Heart and Circulatory Physiology
Oxygen consumption is less in rat hearts arrested by low calcium than by high potassium at fixed flow
Key result
Hypocalcemic arresting solution reduces MVO2 ~15% vs hyperkalemic solution in isolated rat hearts.
- MD -0.004 ml.min-1.g-1
- P<0.01
- n=18
Why the study?
It was unclear whether myocardial oxygen consumption differs between hearts arrested by hyperkalemic versus hypocalcemic solutions at constant coronary flow.
Does hypocalcemic arresting solution reduce myocardial oxygen consumption compared to hyperkalemic arresting solution in isolated rat hearts?
Population
12 isolated Langendorff-perfused rat hearts
Comparison
Hypocalcemic arresting solution (5 mM K+, 0.08 mM Ca2+) vs hyperkalemic arresting solution (20 mM K+, 1.5 mM Ca2+)
Design
Experimental study measuring MVO2 with alternating perfusion solutions
Authors
Discussion
Loading...
Member takes
Implication
Hypocalcemic arrest may lower myocardial energy use during cardioplegia; leaves open whether this improves clinical outcomes versus hyperkalemic solutions.
Structured PICO
Does hypocalcemic arresting solution reduce myocardial oxygen consumption compared to hyperkalemic arresting solution in isolated rat hearts?
P
Population
18 isolated, Langendorff-perfused rat hearts subjected to cardiac arrest with different solutions.
I
Intervention
Hypocalcemic arresting solution (ASCa: 5 mM K+ and 0.08 mM Ca2+)
C
Comparator
Hyperkalemic arresting solution (ASK: 20 mM K+ and 1.5 mM Ca2+)
O
Outcome
Myocardial oxygen consumption (MVO2)surrogate
Main Result
Mean Difference: -0.004
p-value: p=<0.01
Hypocalcemic arrest reduces myocardial oxygen consumption by 15% compared to hyperkalemic arrest in isolated rat hearts.
Cite This Study
Burkhoff et al. (1990) studied Cardiac arrest (experimental) (n=18). Hypocalcemic arresting solution (ASCa) vs. Hyperkalemic arresting solution (ASK) was evaluated on Myocardial oxygen consumption (MVO2) (MD -0.004 ml.min-1.g-1, p=<0.01). In isolated rat hearts, hypocalcemic arresting solution reduced myocardial oxygen consumption by 15% (0.004 ml.min-1.g-1) compared to hyperkalemic arresting solution (P<0.01).