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Systemic lupus erythematosus (SLE, lupus) is the prototype systemic autoimmune disease (AD). Immune system in SLE is characterized by exaggerated B-cell and -cell responses and loss of immune tolerance against selfantigens. and defective elimination of antibodies, and tissue deposition of immune complexes, and and cytokine activation contribute to clinical that range from fatigue and joint pain to , life-threatening organ damage
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Anaya et al. (2014) studied this question.
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