Trichloroacetamides obtained via Overman [3,3] sigmatropic rearrangement were converted into dibenzyl guanidines. The key step was conversion of carbodiimide intermediate into guanidine by scandium or ytterbium trifluoromethane-sulfonates. This method was applied to a synthesis of guanidinium ring of (−)-tetrodotoxin.
No takes yet. Share an insight, caveat, or question.
Yamamoto et al. (1994) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: