Key result
This review examines evidence from recent trials suggesting that functional imaging may help identify patients with early-stage Hodgkin lymphoma for whom radiotherapy can be safely omitted.
Why the study?
Does the omission of radiotherapy guided by functional imaging maintain cure rates and reduce long-term toxicity in patients with early-stage Hodgkin lymphoma?
Does the omission of radiotherapy guided by functional imaging maintain cure rates and reduce long-term toxicity in patients with early-stage Hodgkin lymphoma?
Functional imaging may help identify patients with early-stage Hodgkin lymphoma who can safely omit radiotherapy to avoid long-term toxicity without compromising cure rates.
May support radiotherapy omission via functional imaging in select early-stage Hodgkin lymphoma; leaves open need for prospective validation before practice change.
Although radiotherapy is highly effective for the treatment of Hodgkin lymphoma, the realization of its potential long-term toxicity and the demonstration of excellent results from combination chemotherapy have led to a retreat from its use in early-stage disease. Recent trials using functional imaging may allow better identification of those patients for whom radiotherapy may be safely omitted without compromising cure rates and this review examines the evidence for this.
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Peter Johnson (2013) conducted a review in early-stage Hodgkin lymphoma. Radiotherapy omission guided by functional imaging vs. Standard radiotherapy was evaluated. This review examines evidence from recent trials suggesting that functional imaging may help identify patients with early-stage Hodgkin lymphoma for whom radiotherapy can be safely omitted.
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