Key result
Medications like oral contraceptives are linked to ~15% of triggered thromboses in congenital coagulation inhibitor defects.
Why the study?
The incidence of pharmacological factors, particularly oral contraceptives, as triggers of thrombosis in patients with congenital defects of coagulation inhibitors is commonly considered low but may be underestimated.
Do medications, particularly oral contraceptives, trigger thrombotic events in patients with congenital defects of coagulation inhibitors?
Population
81 symptomatic patients with congenital defects of coagulation inhibitors
Comparison
Thrombotic events triggered by medications, mainly oral contraceptives, versus other triggers
Design
Observational case series
Authors
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May warrant caution with oral contraceptives in this population; leaves open confirmation in larger prospective cohorts.
Observational (n=81)
Do medications, particularly oral contraceptives, trigger thrombotic events in patients with congenital defects of coagulation inhibitors?
Medications, particularly oral contraceptives, are important potential triggers for thrombotic events in patients with congenital defects of coagulation inhibitors.
Girolami et al. (1991) conducted an observational in Congenital defects of coagulation inhibitors (n=81). Medications (mainly oral contraceptives) was evaluated on Thrombotic events triggered by medications. Medications, mainly oral contraceptives, triggered thrombotic events in 15% (6 of 40) of symptomatic patients with congenital defects of coagulation inhibitors who had an identifiable trigger.
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