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same pathogenic pathway and some clinical manifestations, including chilblains and retinal vasculopathy. In addition, this type I IFN response produces microvascular injury, 6 which has already been reported to be related to COVID-19 infection, and it could explain both chilblains and retinal vasculitis. Also, Kawasaki disease can share some similarities with COVID-19 infection. Both cause acral skin lesions, vasculitis and show increased serum interleukin 6 (IL-6) related to the immune response to the disease. 7 Also, there are other viral infections associated with Kawasaki disease, including other species of human coronaviruses. ther types of acral cutaneous lesions apart from chilblains have been reported in patients with COVID-19. This group includes cyanosis, blisters and gangrene in the feet and hands, primarily in adults. Nonetheless, these types of manifestations appear to be related to coagulation disorders in severe cases of COVID-19, and most carry poor prognosis. 9 Our analytical study was rigorously normal, with no poor prognostic data.
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Balestri et al. (2020) studied this question.
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