The hetero-Diels-Alder reaction catalyzed by lanthanum triflate hydrate using diethyl azodicarboxylate as dienophile, yielding differently substituted 1,2,3,6-tetrahydropyridazines, is described.The Diels-Alders reaction is one of the most useful method in synthetic organic chemistry.The use of azo compounds in this process has been known for over seventy years and different types of cyclic and acyclic azodienophiles have been widely employed. 1In particular, azodicarboxylates are very reactive and have been used in combination with many kinds of dienes to synthetize pyridazine heterocycles.The
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Curini et al. (2001) studied this question.
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