Answers are grounded in this paper and cite their sources.
UO22+ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π-π stacking between the two nucleobases in the vicinity of UO22+-bound phosphate. Thereby, the fragility of the DNA backbone increased upon UO22+ binding.
No takes yet. Share an insight, caveat, or question.
Roßberg et al. (2019) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: