A little bit of flexibility: Charged or neutral species can be accommodated in solution and in the solid state by the closed hydrophobic cavity of the first calix[6]arene to adopt a 1,3,5-alternate conformation (see picture, Boc=tert-butoxycarbonyl). The encapsulation involves an induced-fit process that is reminiscent of the rotation of a door and is characterized by large activation barriers for guest exchange.
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Ménand et al. (2009) studied this question.
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