A calix[6]arene has been rigidified by three primary ammonium arms self-assembled with the counter anions. This supramolecular edifice provides a well-defined conic hydrophobic cavity closed at the narrow rim by a tricationic site. X-ray and NMR analyses show that the resulting polarized host behaves as a remarkable endo-receptor for small molecules such as amides, alcohols and even nitriles. This study highlights the efficiency of a system that associates a cationic site with a hydrophobic cavity to host dipolar neutral molecules.
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Darbost et al. (2005) studied this question.
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