Key result
Non-hypertensive acromegaly linked to ~248% higher fQRS prevalence versus controls, correlating with increased LVH.
Why the study?
The relationship between fragmented QRS formation and left ventricular hypertrophy parameters in nonhypertensive acromegaly patients was not well defined.
Is the presence of fragmented QRS associated with increased left ventricular hypertrophy parameters in patients with non-hypertensive acromegaly?
Observational (n=95)
Is the presence of fragmented QRS associated with increased left ventricular hypertrophy parameters in patients with non-hypertensive acromegaly?
Absolute Event Rate: 36.2% vs 10.4%
p-value: p=0.003
Fragmented QRS on ECG is a useful marker associated with increased left ventricular hypertrophy and longer disease duration in patients with non-hypertensive acromegaly.
Background/aim: It is known that the presence of fragmented QRS (fQRS) on electrocardiography (ECG) is associated with cardiovascular events. The aim of this study was the evaluation of fQRS formation and its relationship with the left ventricular hypertrophy (LVH) parameters in acromegaly patients. Materials and methods: In total, 47 previously diagnosed with non-hypertensive acromegaly patients and 48 control subjects were included in the study. ECG and transthoracic echocardiography (TTE) were performed for each participant. Acromegaly patients were divided into two groups according to the fQRS formation on the ECG. Left ventricular wall thicknesses, and left atrial diameter (LAD), left ventricular mass (LVM), left ventricular mass index (LVMi), and relative wall thickness (RWT) were obtained. Results: In control group 5 (10.4%) and in acromegaly group 17 (36.2%) patients had fQRS on ECG (p = 0.003). LAD [36.0 (34.0–38.0) vs. 38.0 (35.0–41.0) mm, p < 0.001], LVM [155.27 ± 27.00 vs. 173.0 (153.0–235.0) g, p < 0.001], LVMi [83.12 ± 13.19 vs. 92.0 (83.0–118.0) g/m², p < 0.001] and RWT [0.39 ± 0.03 vs. 0.43 (0.41–0.45), p = 0.001] were significantly higher in patients with acromegaly. Disease duration was significantly higher (11.59 ± 1.3 vs. 8.2 ± 1.8 years, p < 0.001) in the fQRS (+) group. LAD [41.0 (39.0–42.5) vs. 37.0 (34.7–38.0) mm, p < 0.001], LVM [219.0 (160.5–254.5) vs. 164.0 (153.0–188.0) g, p = 0.017], LVMi [117.0 (92.5–128.5) vs. 86.0 (82.0–100.2) g/m², p = 0.013] and RWT [0.44 (0.42–0.49) vs. 0.43 (0.40–0.44), p = 0.037] were significantly higher in fQSR (+) acromegaly patients. In multivariate logistic regression analysis, disease duration (odds ratio: 10.05, 95% CI: 1.099–92.012, p = 0.041) and LAD (odds ratio: 2.19, 95% CI: 1.030–4.660, p = 0.042) were found to be the independent predictors of fQRS formation. Conclusion: The results of our study revealed that fQRS (+) acromegaly patients had increased LVH parameters compared to fQRS (-) patients.
No takes yet. Share an insight, caveat, or question.
Dural et al. (2021) conducted an observational in Non-hypertensive acromegaly (n=95). Non-hypertensive acromegaly vs. Control subjects was evaluated on Fragmented QRS (fQRS) on ECG (p=0.003). Non-hypertensive acromegaly was associated with a higher prevalence of fragmented QRS compared to controls (36.2% vs 10.4%, p=0.003), which correlated with increased left ventricular hypertrophy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: