Glomeruloid reactive angioendotheliomatosis in a woman with systemic lupus erythematosus and antiphospholipid syndrome mimicking reticular erythematous mucinosis

The umbrella term “cutaneous reactive angiomatoses” was introduced in 2003 to include uncommon angioproliferative (capillary) cutaneous conditions, which present with variable clinical features and involve patients with a variety of underlying systemic conditions.1 Histologically, these disorders are characterized by different patterns of intravascular or extravascular lobular or diffuse hyperplasia of endothelial cells, pericytes, and, sometimes, histiocytes, mostly throughout the dermis.1 The first condition to be described was reactive angioendotheliomatosis (RAE), which is usually associated with prothrombotic conditions.