Key result
ARMAX modeling adequately captures the PVC rate response to lidocaine infusion in ~80% of canine trials.
Why the study?
Modeling the PVC rate and its response to intravenous lidocaine infusion was needed to facilitate the design of a closed-loop drug infusion system.
Population
Canine model of myocardial infarction
Comparison
PVC rate response to varying lidocaine infusion rates
Design
System identification experiments using ARMAX modeling
Authors
Loading...
May support closed-loop lidocaine controller design; hypothesis-generating in canine data only, no practice change.
An autoregressive moving average model can adequately represent the dynamics of PVC rate response to lidocaine infusion in a canine model, which may facilitate the design of closed-loop drug infusion systems.
Jannett et al. (1987) studied Myocardial infarction (canine model). Lidocaine infusion was evaluated on Adequate representation of the PVC rate by ARMAX model. First-order ARMAX models provided an adequate representation of the PVC rate response to lidocaine infusion in eight of ten experimental runs in a canine model.
Synapse has enriched one closely related paper. Consider it for comparative context: