Key result
Obesity is linked to higher serum cystatin C levels, independently predicted by waist circumference.
Why the study?
Data suggesting that cystatin C levels are linked to obesity, apart from renal pathology, are conflicting.
Cross-Sectional (n=132)
No
Cystatin C levels are independently associated with abdominal obesity (waist circumference) in healthy middle-aged adults, independent of renal function.
Answers are grounded in this paper and cite their sources.
Cystatin C was associated with abdominal obesity independent of eGFR; leaves open its value as a cardiometabolic marker beyond renal assessment.
Introduction: Data suggesting that cystatin C levels are linked to obesity, apart from renal pathology, are conflicting. The aim of the study was to explore the potential association between serum cystatin C levels, anthropometric, and cardiometabolic parameters in healthy middle-aged adults.Methods: A total of 132 participants (mean age 56.2 ± 6.73 years, 69% females) were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained.Results: Obese participants displayed higher cystatin C levels than normal-weight participants (p < 0.001). Multiple linear regression analysis revealed that waist circumference (WC) (Beta = 0.376, p < 0.001) and estimated glomerular filtration rate (Beta = -0.484, p < 0.001) were independently associated with cystatin C levels (R2 = 0.447; p < 0.001).Conclusions: Cystatin C is associated with abdominal obesity independent of renal function. Its relationship with changes in other target organs should be determined.
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Jovanović et al. (2016) conducted a cross-sectional in Healthy middle-aged adults (n=132). Obesity vs. Normal weight was evaluated on Serum cystatin C levels (mg/L) (p=<0.001). Obese participants had significantly higher median serum cystatin C levels compared to normal-weight participants (0.81 vs 0.75 mg/L, p < 0.001), with waist circumference acting as an independent predictor.
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