Vitamin C deficiency can result in scurvy, a condition that can mimic a rheumatic disease. In humans the L-gul-ono-γ-lactone oxidase gene prevents coding for the enzyme required to convert glucose to ascorbic acid (vitamin C)1,2. Consequently, humans require exogenous vitamin C. Scurvy can occur in children whose diet is restricted …
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Rumsey et al. (2013) studied this question.
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