Key result
Hypertension is linked to ~6-fold higher odds of accelerated arterial aging in adults without CVD.
Why the study?
Biological age is a better predictor of morbidity and mortality than chronological age, but the association of cardiovascular risk factors with the rate of aging in people without cardiovascular diseases is unclear.
Observational (n=143)
Accelerated arterial aging is significantly associated with hypertension and elevated glycated hemoglobin in adults without established cardiovascular disease.
Answers are grounded in this paper and cite their sources.
May flag higher-risk adults without CVD; hypothesis-generating and requires prospective validation.
Background: Biological age is a better predictor of morbidity and mortality associated with chronic age-related diseases than chronological age. The estimated difference between biological and chronological age can reveal an individual’s rate of aging. Aim: The aim of this study was to assess the association of cardiovascular risk factors with the rate of aging in people without cardiovascular diseases. Materials and methods: We calculated biological artery age and found associations of “old” arteries and rate of aging with risk factors of cardiovascular diseases in 143 adults without cardiovascular diseases. The data were analyzed by their categorization into 3 tertiles using regression methods. Results: The increased biological age of the arteries compared to the chronological age was associated with the chronological age (p < 0.001; ОR = 0.55; 95% CI: 0.43–0.71) and hypertension (p = 0.002; ОR = 6.04; 95% CI: 1.98–18.42) in general group, age (p < 0.001; ОR = 0.45; 95% CI: 0.30–0.68), hypertension (p = 0.004; ОR = 12.79; 95% CI: 2.25–72.55) and family history of oncology (p = 0.036; ОR = 0.14; 95% CI: 0.02–0.88) in women subgroup and age (p = 0.001; ОR = 0.45; 95% CI: 0.28–0.76) and 3rd tertile of glycated hemoglobin (p = 0.041; ОR = 65.05; 95% CI: 1.19–3548.29) in men subgroup. Difference between biological and chronological age in a group of “old” arteries was associated with chronological age (p = 0.001; β = –1.24; 95% CI: –1.95…–0.53) and with chronological age (p < 0.001; β = 1.71; 95% CI: 1.06–2.36) and 3rd tertile of glycated hemoglobin (p = 0.009; β = –4.78; 95% CI: –8.32…–1.24) in group of “young” arteries. Conclusion: This study demonstrates that accelerated arterial aging is associated with hypertension and high levels of glycated hemoglobin.
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Akopyan et al. (2023) conducted an observational in Without cardiovascular diseases (n=143). Cardiovascular risk factors (hypertension and glycated hemoglobin) vs. Absence of risk factors or lower tertiles was evaluated on Increased biological age of the arteries compared to chronological age (OR 6.04, 95% CI 1.98-18.42, p=0.002). Accelerated arterial aging was significantly associated with hypertension (OR 6.04; 95% CI 1.98-18.42; p=0.002) and high levels of glycated hemoglobin in adults without cardiovascular diseases.
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