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November 29, 2012Cell CycleOpen Access

Transactivation by low and high levels of human p53 reveals new physical rules of engagement and novel super-transactivation sequences

Daniel Menéndez Michael A. Resnick Tali E. Haran

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Abstract

Regulated transcription requires transcription factors (TFs) and targeted response element sequences (REs). Variations in TF levels and sequence can “tune” a regulatory network. Although there is c...

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Cite This Study

Menéndez et al. (2012) studied this question.

synapsesocial.com/papers/6ab20795874cdcc863ff418e https://doi.org/10.4161/cc.22467

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversityOriginal Research · 2003 · 151 citations
2Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53Original Research · 2008 · 103 citations
3Low-level p53 expression changes transactivation rules and reveals superactivating sequencesOriginal Research · 2012 · 34 citations
4Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targetsOriginal Research · 2010 · 53 citations
5DNA sequence-dependent deformability deduced from protein–DNA crystal complexesOriginal Research · 1998 · 1,038 citations

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