We were very interested in the recent paper by Moore et al. (3) in which the authors used transposon mutants to demonstrate efflux-mediated resistance to aminoglycosides and macrolides in Burkholderia (formerly Pseudomonas)pseudomallei. Melioidosis is very difficult to treat because of intrinsic resistance to many antimicrobial agents, particularly the aminoglycosides. Aminoglycoside–β-lactam combinations are used empirically to treat suspected community-acquired sepsis in many areas of the world, but they are ineffective in melioidosis.
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Simpson et al. (1999) studied this question.
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