Answers are grounded in this paper and cite their sources.
BACKGROUND: Current information on the health effects and toxicology of talc suggests that this may lead to a specific target organ toxicity arising from repeated exposure (STOT-RE) classification. OBJECTIVE: To provide an assessment of the currently available inhalation toxicity data on talc and to put these data in the perspective of other poorly soluble low-toxicity particles. METHODS: A database of 177 articles was gathered from different sources. RESULTS: Relevant animal data sets were subjected to a quality review, and epidemiological studies on talc and lung effects published since 2016 were reviewed. CONCLUSIONS: Of nine original inhalation studies reviewed, only one study using rats and mice met the criteria that are needed to include for a reliable evaluation for STOT-RE. Together with the pulmonary effects observed in exposed talc miners, a STOT-RE 1 classification is warranted.
No takes yet. Share an insight, caveat, or question.
Paul Borm (2022) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: