Key result
Hypernatremia was associated with a threefold increase in the hazard of ICU death among patients with severe traumatic brain injury.
Why the study?
Does routine administration of hypertonic saline increase mortality in patients with traumatic brain injury?
Does routine administration of hypertonic saline increase mortality in patients with traumatic brain injury?
The association between hypernatremia and mortality in traumatic brain injury warrants a re-evaluation of routine hypertonic saline use for intracranial hypertension.
There is mounting evidence, including the recent report by Maggiore and colleagues, of an association between hypernatremia and mortality in patients with traumatic brain injury. This mandates a re-evaluation of routine administration of agents such as hypertonic saline for the management of intracranial hypertension in those with traumatic brain injury.
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David A. Zygun (2009) conducted an editorial in Severe traumatic brain injury (n=130). Hypernatremia vs. No hypernatremia was evaluated on ICU death (threefold increase in hazard). Hypernatremia was associated with a threefold increase in the hazard of ICU death among patients with severe traumatic brain injury.
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