Key result
Novel A3 receptor agonist Compound 7 shows unprecedented selectivity to potentially prevent myocardial ischemic injury.
Why the study?
Selective adenosine A3 agonists have potential utility for preventing perioperative myocardial ischemic injury, but highly selective agonists were lacking.
The discovery of compound 7 provides a highly selective human adenosine A3 receptor agonist with potential utility for preventing perioperative myocardial ischemic injury.
Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of selectivity for the human adenosine A(3) receptor.
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DeNinno et al. (2002) studied this question. Compound 7 is a newly synthesized amino nucleoside agonist demonstrating unprecedented selectivity for the human adenosine A3 receptor, with potential to prevent myocardial ischemic injury.
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