Key result
Intracranial hemorrhage is linked to ~157% higher plasma renin activity than ischemic stroke.
Why the study?
The relationship between plasma renin activity and different types of acute cerebrovascular disease was not well characterized.
Is plasma renin activity elevated in acute cerebrovascular disease?
Observational (n=22)
Is plasma renin activity elevated in acute cerebrovascular disease?
Plasma renin activity is significantly elevated in acute intracranial hemorrhage compared to ischemic cerebrovascular disease, potentially relating to autonomic changes or vasospasm.
Answers are grounded in this paper and cite their sources.
Should not yet change stroke management; leaves open renin as biomarker or target in hemorrhage.
A preliminary study of plasma renin activity was made in 22 patients with acute cerebrovascular disease. Eight of 12 patients with intracranial hemorrhage had plasma renin activity values above the normal range of 30 to 330 ng/100 ml plasma, but only one of ten patients with ischemic cerebrovascular disease had increased plasma renin activity. The mean values for the two groups were, respectively, 489 and 190 ng/100 ml plasma (P for difference < 0.001). Ten days later plasma renin activity was normal in each of three patients with intracranial hemorrhage. The acute increase of plasma renin activity may have been associated with altered activity of the autonomic nervous system, and may be related to posthemorrhagic vascular events such as vasospasm.
No takes yet. Share an insight, caveat, or question.
MORAN et al. (1973) conducted an observational in Acute cerebrovascular disease (n=22). Intracranial hemorrhage vs. Ischemic cerebrovascular disease was evaluated on Mean plasma renin activity (ng/100 ml plasma) (p=< 0.001). Patients with intracranial hemorrhage had significantly higher mean plasma renin activity compared to those with ischemic cerebrovascular disease (489 vs 190 ng/100 ml plasma; P<0.001).
Synapse has enriched 10 related papers. Consider them for comparative context: