Despite the introduction of effective vaccination programs in a substantial number of countries, it is anticipated that in the coming decades many hepatitis B virus (HBV)-infected patients will die from liver failure or hepatocellular carcinoma. Effective antiviral therapy may decrease the incidence of this HBV-related mortality, which is currently estimated around one million annually worldwide [1]. Permanent and complete suppression of viral replication is the main treatment goal of antiviral therapy with nucleos(t)ide analogues (NA) for chronic HBV infection [2–4].
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Janssen et al. (2009) studied this question.
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