Key result
Advances in stroke genetics enable new avenues for risk prediction, pharmacogenomics, and drug discovery.
Why the study?
Rapid advances in medical and population genetics of stroke have created new opportunities for discovery and clinical applications that require synthesis and overview.
This review highlights the rapid advancements in stroke genetics, emphasizing the transition from genetic discoveries to potential clinical applications like risk prediction and pharmacogenomics.
Stroke genetic advances may inform future risk stratification; leaves open clinical translation pending prospective validation.
The field of medical and population genetics in stroke is moving at a rapid pace and has led to unanticipated opportunities for discovery and clinical applications. Genome-wide association studies have highlighted the role of specific pathways relevant to etiologically defined subtypes of stroke and to stroke as a whole. They have further offered starting points for the exploration of novel pathways and pharmacological strategies in experimental systems. Mendelian randomization studies continue to provide insights in the causal relationships between exposures and outcomes and have become a useful tool for predicting the efficacy and side effects of drugs. Additional applications that have emerged from recent discoveries include risk prediction based on polygenic risk scores and pharmacogenomics. Among the topics currently moving into focus is the genetics of stroke outcome. While still at its infancy, this field is expected to boost the development of neuroprotective agents. We provide a brief overview on recent progress in these areas.
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Dichgans et al. (2021) conducted a review in Stroke. Recent advances in stroke genetics, including genome-wide association studies and Mendelian randomization, offer new opportunities for risk prediction, pharmacogenomics, and drug discovery.
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