Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions

Roman Mehling; Johannes Schwenck; Christina Lemberg; Christoph Trautwein; Laimdota Zizmare; Daniela Kramer; Anne Müller; Birgit Fehrenbacher; Irene González-Menéndez; Leticia Quintanilla‐Martínez; Katrin Schröder; Martin Schaller; Wolfram Ruf; Martin Eichner; Kamran Ghoreschi; Martin Röcken; Bernd J. Pichler; Manfred Kneilling

doi:10.7150/thno.51462

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Abstract

MPO and NOX2 are the dominant sources of ROS/RNS in acute and chronic DTHR. Nevertheless, depletion of one primary source of ROS/RNS exhibited only marginal but conflicting impact on acute and chronic cutaneous DTHR. Thus, ROS/RNS are not a single entity, and each species has different properties at certain stages of the disease, resulting in different outcomes.

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Mehling et al. (2020) studied this question.

synapsesocial.com/papers/6ab21a9f4e434048c1776523 https://doi.org/10.7150/thno.51462

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Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions

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Abstract

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Cite This Study

Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions

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Abstract

Discussion

Cite This Study

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