Comparative analysis of valproic acid concentrations in terms of dosing and clinical effect monitoring in different age patients with diagnosed epilepsy

Comparative analysis of valproic acid concentrations in terms of dosing and clinical effect monitoring in different age patients with diagnosed epilepsy Subject of research.Therapy drug monitoring under the control of valproic acid (VPA) is now a well-established tool for the treatment of epilepsy.The pharmacokinetic variability of VPA and interindividual differences in epilepsy type/seizure severity depending on patients' age determine the serum concentration of this drug in an individual patient.The application of the "individual therapeutic concentration" may be a useful indicator taking into account the clinical condition of a patient.Aim.The aim was to compare values of stationary VPA concentrations in terms of dosing and clinical effect monitoring in epileptic patients of different ages.Methods.Thirty-three patients at age 20-70 years were divided into three groups: I -20-25 years (n = 15), II -26-39 years (n = 9), III -40-70 years (n = 9).Nine patients were treated with VPA in Adres do korespondencji