Key result
A novel H3N2 reassortant virus derived from swine H3N2 and human H7N9 viruses caused fatal acute encephalitis in a 7-year-old boy and exhibited natural resistance to neuraminidase inhibitors.
Case Report (n=1)
No
Identifies a fatal human case of acute encephalitis caused by a novel, highly pathogenic swine-human reassortant H3N2 influenza virus, highlighting the need for enhanced genomic surveillance.
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Raises caution for novel reassortant influenza encephalitis in children; leaves open zoonotic transmission dynamics pending surveillance data.
Wang et al. (2025) conducted a case report in Acute encephalitis caused by a novel H3N2 reassortant virus (n=1). Novel H3N2 reassortant virus (A/Yixing/805/2022) was evaluated on Clinical and virological features of fatal encephalitis. A novel H3N2 reassortant virus derived from swine H3N2 and human H7N9 viruses caused fatal acute encephalitis in a 7-year-old boy and exhibited natural resistance to neuraminidase inhibitors.
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