Actual circulating blood volume during dialysis therapy can be monitored by continuous hemoglobinometry. Using this method in 15 stable, clinically nonoverhydrated dialysis patients, blood volume was recorded applying different modes of ultrafiltration: constant ultrafiltration (less than 500 ml/hr); high initial (greater than 1,500-2,000 ml/hr), subsequently decreasing ultrafiltration; and intermittently high (greater than 1,500 ml/hr) ultrafiltration. Mean amount of ultrafiltrate in all patients was 3,400 ml. Mean decrease in blood volume by 20% was generally tolerated without a decrease in blood pressure. Irrespective of the different modes of ultrafiltration, a decrease in blood volume was dependent only on the amount of ultrafiltered fluid. A constant, low ultrafiltration rate was not superior to a high ultrafiltration rate. In stable dialysis patients, decrease in blood volume is dependent only on the amount of ultrafiltrate. Up to a 20% decrease in blood volume, fluid can be removed from the patient even at a rate of 2,000 ml/hr.
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Mann et al. (1989) studied this question.