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(1) A high degree of resistance to proguanil was developed in a strain of P. knowlesi which was subjected to periodic exposure to the drug at varying intervals for one year. (2) The effect was persistent even after 8 months during which time no further proguanil was administered during serial passages. (3) The proguanil-resistant strain was found to be refractory to daraprim and bromoguanide but not so to sulphadiazine, M 3349 nor chloroquin.
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Singh et al. (1952) studied this question.
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