Electrochemical Activation of Screen Printed Carbon Electrode for the Determination of Antibiotic Drug Metronidazole

Metronidazole (MTZ) is a potential drug for the treatment of antibiotic and antiprotozoal medications. However, the drug over dosage or contaminated water from the drug industry makes the human to fatal disease. Therefore, in this work we have concentrated the determination of metronidazole by the electrochemical technique. Thereby, we have utilized the activated screen printed carbon electrode (ASPCE) for the determination. This electrode was prepared by simple electrochemical cyclic voltammetry technique. Wherein, the SPCE was pre-anodized in the phosphate buffer solution and directly used for the determination. This electrode provides the better performance when compared with bare electrode. Moreover, it provides the selective and sensitive determination towards the MTZ with linear concentration ranges 0.05 - 563 µM; 753 - 2873 µM and the lowest detection limit 0.01 µM. The developed disposable sensor electrode is low cost and revealed high repeatability and reproducibility.