Key result
Elevated IGF-1, TNF-α, and VEGF165 linked to the presence and severity of type 2 diabetic nephropathy.
Why the study?
The associations between serum levels of IGF-1, TNF-α, and VEGF 165 and the occurrence and progression of type 2 diabetic nephropathy were not well defined.
Case-Control (n=205)
Elevated serum levels of IGF-1, TNF-α, and VEGF165 are associated with the presence and severity of type 2 diabetic nephropathy.
Serum IGF-1, TNF-α, and VEGF165 levels were associated with DN progression; leaves open whether they improve risk prediction or guide therapy in type 2 diabetes.
Aims/Introduction The present study aimed to determine the associations between expressions of insulin‐like growth factor‐1 ( IGF ‐1), tumor necrosis factor‐α ( TNF ‐α) and vascular endothelial growth factor 165 ( VEGF 165 ) in serum, and occurrence and development of type 2 diabetic nephropathy ( DN ). Materials and Methods A total of 108 patients diagnosed as DN were randomly selected, including 50 patients in the microalbuminuria group, 44 patients in the macroalbuminuria group and 14 patients in the renal insufficiency group. Meanwhile, 97 healthy people were collected as a normal control group. Urinary albumin ( UALB ) and urine creatinine (Cr) of all participants were measured for 24 h, with their ratio ( UALB /Cr) being calculated. Enzyme‐linked immunosorbent assay was used to detect the serum concentrations of IGF ‐1, TNF ‐α and VEGF 165 . Results The expressions of serum IGF ‐1, TNF ‐α and VEGF 165 in the type 2 DN patients were significantly higher than those in the control group (all P < 0.05). The expressions of serum IGF ‐1, TNF ‐α and VEGF 165 in the type 2 DN patients were positively correlated with UALB /Cr (all P < 0.05). As type 2 DN worsened, the expressions of serum IGF ‐1, TNF ‐α and VEGF 165 increased, and type 2 DN severity had positive correlations with serum IGF ‐1, TNF ‐α and VEGF 165 concentrations (all P < 0.05). There was a positive association between IGF ‐1 and TNF ‐α, IGF ‐1 and VEGF 165 , and TNF ‐α and VEGF 165 (all P < 0.05). Logistic regression analysis showed that IGF ‐1 and VEGF 165 were associated with the progression of DN (both P < 0.05). Conclusions Elevated expression levels of serum IGF ‐1, TNF ‐α and VEGF 165 might exacerbate type 2 DN .
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Li et al. (2016) conducted a case-control in Type 2 diabetic nephropathy (n=205). Elevated serum levels of IGF-1, TNF-α, and VEGF165 vs. Healthy controls was evaluated on Presence and severity of type 2 diabetic nephropathy (p=<0.05). Elevated serum levels of IGF-1, TNF-α, and VEGF165 were significantly associated with the presence and severity of type 2 diabetic nephropathy compared to healthy controls (all P<0.05).
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