Key result
Endothelial cell resilience despite existing risk factors warrants molecular research for novel therapeutic approaches.
Why the study?
Recent studies exploring the basis for absence of cardiovascular disease despite existing risk factors, known as resilience, are adding new knowledge and suggesting novel therapeutic approaches focused on endothelial function.
This perspective highlights the need for a paradigm shift toward understanding endothelial cell resilience to identify novel therapeutic approaches for cardiovascular disease.
Supports paradigm shift toward endothelial resilience research; leaves open its molecular targets and clinical translation.
Traditionally, much research effort has been invested into focusing on disease, understanding pathogenic mechanisms, identifying risk factors, and developing effective treatments. A few recent studies unraveling the basis for absence of disease, including cardiovascular disease, despite existing risk factors, a phenomenon commonly known as resilience, are adding new knowledge and suggesting novel therapeutic approaches. Given the central role of endothelial function in cardiovascular health, we herein provide a number of considerations that warrant future research and considering a paradigm shift toward identifying the molecular underpinnings of endothelial resilience.
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Gao et al. (2020) conducted a review in Cardiovascular disease. Endothelial cell resilience was evaluated. Endothelial cell resilience, the absence of cardiovascular disease despite existing risk factors, warrants future research to identify its molecular underpinnings for novel therapeutic approaches.
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