Key result
The combined presence of non-cancer chronic pain conditions and multimorbidity significantly increased the risk of incident Alzheimer's disease and related dementias (AOR 1.72) compared to the absence of both.
Why the study?
Does the presence of non-cancer chronic pain conditions accompanied by multimorbidity increase the risk of incident Alzheimer's Disease and Related Dementias in older adults?
Cohort (n=16,934)
Does the presence of non-cancer chronic pain conditions accompanied by multimorbidity increase the risk of incident Alzheimer's Disease and Related Dementias in older adults?
The combination of multimorbidity and non-cancer chronic pain conditions significantly increases the risk of incident Alzheimer's Disease and Related Dementias in older adults.
May prompt closer cognitive monitoring in older adults with chronic pain plus multimorbidity; leaves open causal pathways and preventive interventions.
Objective Multimorbidity and non-cancer chronic pain conditions (NCPC) are independently linked to elevated risk for cognitive impairment and incident Alzheimer’s Disease and Related Dementias (ADRD)-both - We present the study of potential joint and interactive effects of these conditions on the risk of incident ADRD in older population.Methods This retrospective-cohort study drew baseline and 2-year follow-up data from linked Medicare claims and Medicare Current Beneficiary Survey (MCBS). Baseline multimorbidity and NCPC were ascertained using claims data. ADRD was ascertained at baseline and follow-up.Results NCPC accompanied by multimorbidity (vs. absence of NCPC or multimorbidity) had a significant and upward association with incident ADRD (adjusted odds ratio (AOR): 1.72, 95% CI 1.38, 2.13, p < 0.0001). Secondary analysis by number of comorbid conditions suggested that the joint effects of NCPC and multimorbidity on ADRD risk may increase with rising number contributing chronic conditions. Interaction analyses indicated significantly elevated excess risk for incident ADRD.
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Khalid et al. (2023) conducted a cohort in Alzheimer's Disease and Related Dementias (ADRD) (n=16,934). Non-cancer chronic pain conditions (NCPC) and multimorbidity vs. Absence of NCPC and multimorbidity was evaluated on Incident Alzheimer's Disease and Related Dementias (ADRD) (AOR 1.72, 95% CI 1.38, 2.13, p=<0.0001). The combined presence of non-cancer chronic pain conditions and multimorbidity significantly increased the risk of incident Alzheimer's disease and related dementias (AOR 1.72) compared to the absence of both.
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