Synthesis of an 11-deoxy-8-azaprostaglandin E1 intermediate

In recent years considerable chemical and medicinal interest been focused on prostaglandin analogues in which atoms are replaced by heteroatoms.' Among the azaprostaglandin, which contain one or more nitrogens almost ever) position of the cyclopentane nucleus, the1 l-deoxy-8-azai)rostaglandin El (1) is of special interest because the atti active biological activities.