Key result
FLIPR enables subsecond simultaneous optical screening across all 96 wells for cell-based kinetic assays.
Why the study?
Modern optical screening assays require high data throughput combined with uncompromised data fidelity for cell-based kinetic assays.
Population
Cell-based kinetic assays
Design
Development of FLIPR instrument with integrated optical detection, temperature control, and fluid handling
Authors
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Accelerates high-throughput cell-based screening in cardiovascular research; leaves open clinical translation.
FLIPR enables accurate, high-throughput optical screening for cell-based kinetic assays by simultaneously stimulating and measuring all 96 wells of a standard microplate.
Schroeder et al. (1996) studied this question. FLIPR (Fluorescent Imaging Plate Reader) was evaluated on Measurements of intracellular calcium, intracellular pH, and membrane potential. FLIPR enables simultaneous optical measurement of all 96 wells of a standard microplate with kinetic updates in under 1 second for cell-based assays.
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