Key result
Mild biliary acute pancreatitis was not associated with differences in leptin, adiponectin, insulin, or HOMA-IR levels compared to healthy controls, though adiponectin increased in remission.
Why the study?
Do leptin and adiponectin levels differ between patients with mild biliary acute pancreatitis and healthy controls?
Case-Control (n=48)
Do leptin and adiponectin levels differ between patients with mild biliary acute pancreatitis and healthy controls?
Adiponectin levels increase during remission in mild biliary acute pancreatitis, which may indicate clinical improvement.
Adiponectin rise may mark recovery in mild pancreatitis; leaves open adipokine differences versus controls and needs prospective confirmation.
OBJECTIVES: Obesity markedly increases the risk of severe acute pancreatitis (AP). Several adipokines have been ascribed a role as a predictor of clinical severity in AP. Therefore, the aim of this study was to investigate a possible relationship between leptin and adiponectin and mild biliary AP. METHODS: We included 24 consecutive patients with mild biliary AP and 24 consecutive healthy age- and sex-matched controls. Clinical severity was classified by the Ranson score. ELISA was used to assess leptin and adiponectin levels on admission and in remission. Complete blood cell counts and other laboratory tests were also performed at baseline and in remission. RESULTS: Leptin, adiponectin, insulin and HOMA-IR measurements showed no difference in pancreatitis patients both on admission and in remission compared to the control group. No difference was found in leptin, insulin or HOMA-IR levels in the course of pancreatitis. However, adiponectin levels were higher in remission compared to admission. CONCLUSIONS: Increased adiponectin levels in remission may be an indication of improvement in this condition. Further studies are needed to determine whether adiponectin provides protection from AP.
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Demirci et al. (2012) conducted a case-control in Mild biliary acute pancreatitis (n=48). Mild biliary acute pancreatitis vs. Healthy age- and sex-matched controls was evaluated on Leptin, adiponectin, insulin and HOMA-IR levels. Mild biliary acute pancreatitis was not associated with differences in leptin, adiponectin, insulin, or HOMA-IR levels compared to healthy controls, though adiponectin increased in remission.
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