Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19

The clinical picture of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)/coronavirus disease 2019 (COVID‐19)‐related acute respiratory syndrome is often associated with a coagulopathy.1 An elevated D‐dimer has been linked with an unfavourable prognosis in patients with COVID‐19. In a recent cohort study, 71% of patients who died matched the International Society of Thrombosis and Hemostasis (ISTH) criteria for disseminated intravascular coagulation (DIC)2, while this percentage was only 0·6% in patients who survived.