Quantitative data analysis ofin vivoMRS data sets

The different characteristics between frequency domain and time domain analysis techniques are detailed for their application to in vivo MRS data sets. With the aim of quantitative analysis of MRS signals, i.e. estimation of parameters in the physical model function that describes the MRS experiment, it is considered desirable to avoid any preprocessing of the data, resulting in a preference for time domain parameter estimation techniques. A historical overview is provided for the time domain analysis methods presented in the literature, and a number of time domain methods are described in detail. Finally, the MRUI software package, providing an interactive graphical user interface for a variety of time domain methods, is summarized.