Key result
Excessive inflammation drives cardiovascular disease progression across atherosclerosis, ischemic heart disease, and heart failure.
Why the study?
The dual role of inflammation in preserving cellular integrity and contributing to various diseases including ischemic heart disease and heart failure is complex and requires clarification.
Provides a general overview of the dual role of inflammation in preserving cellular integrity versus contributing to various diseases including cardiovascular conditions.
Cautions against unchecked inflammation in cardiovascular patients; leaves open targeted interventions for atherosclerosis and heart failure.
Activation of inflammatory reactions by the immune system is of vital importance to the preservation of cellular and organ integrity in a hostile environment. It is a complex and fine-tuned mechanism. Insufficient response may cause immunodeficiency resulting in infection and cancer while overactivity may result in diseases like arthritis, diabetes, atherosclerosis, ischemic heart disease, heart failure, stroke, inflammatory bowel disease or Alzheimer's disease.
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John Kjekshus (2015) conducted a review in Inflammation. Inflammation was evaluated. Inflammatory reactions are vital for cellular integrity, but overactivity can lead to various diseases including atherosclerosis, ischemic heart disease, and heart failure.
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