Key result
Pharmacogenetic table dosing improves initial warfarin dose accuracy ~28% over empiric strategies.
Why the study?
The accuracy of the pharmacogenetic dosing table in the warfarin label compared to empiric dosing strategies in predicting initial therapeutic warfarin doses was unclear.
Does the pharmacogenetic dosing table in the warfarin label improve the accuracy of predicting initial therapeutic warfarin doses compared to empiric dosing strategies in patients on stable warfarin therapy?
Cohort (n=3,727)
Yes
Does the pharmacogenetic dosing table in the warfarin label improve the accuracy of predicting initial therapeutic warfarin doses compared to empiric dosing strategies in patients on stable warfarin therapy?
The pharmacogenetic dosing table in the warfarin label provides more accurate initial dose predictions than empiric dosing strategies across diverse racial groups.
May improve initial warfarin dose accuracy; hypothesis-generating and requires prospective validation before practice change.
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Shin et al. (2011) conducted a cohort in Patients requiring warfarin therapy (n=3,727). Pharmacogenetic dosing table in the warfarin label vs. Empiric dosing strategies (warfarin 5 mg/day or race-based dosing) was evaluated on Mean percentage of patients whose predicted doses were within 20% of their actual therapeutic doses. The pharmacogenetic dosing table predicted initial therapeutic warfarin doses with higher accuracy (41.5% within 20% of actual dose) compared to empiric dosing strategies (31.8-32.7%).
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