Molecular modelling has been used successfully to predict the stabilisation of crystalline nanosuspensions of model pharmaceutical drugs by the surfactant Polysorbate 80. The ratio of the binding energy of the Polysorbate 80 to the binding energy of the drug to the surface of the crystal was found to correlate with the stabilisation of the nanosuspension.
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Konkel et al. (2008) studied this question.
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