Key result
NO-targeting gene therapy reduces atherosclerotic lesions by ~20% in preclinical models.
Why the study?
Atherosclerosis in the elderly is influenced by complex risk factors including aging and endothelial dysfunction, and current treatments have not achieved complete regression of lesions.
Regression of atherosclerosis may be achievable through strategies that regulate nitric oxide bioavailability and free radical scavengers to prevent endothelial senescence.
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May support NO-based regression of elderly atherosclerosis; leaves open whether this alters clinical events.
Hayashi et al. (2010) conducted a review in Atherosclerosis. Regulation of nitric oxide and free radical scavengers was evaluated. NO targeting gene therapy regressed 20% of atherosclerotic lesions in animal models, suggesting regulation of NO and free radicals may achieve regression of atherosclerosis.
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