Key result
The R-Biopharm RIDA®QUICK Norovirus IC assay demonstrated high sensitivity and specificity comparable to PCR-based methods, with zero false positives or false negatives detected.
Why the study?
Does the R-Biopharm RIDA®QUICK Norovirus IC assay accurately detect norovirus compared to RT-PCR in children hospitalized with acute gastroenteritis?
Cross-Sectional
Does the R-Biopharm RIDA®QUICK Norovirus IC assay accurately detect norovirus compared to RT-PCR in children hospitalized with acute gastroenteritis?
The RIDA®QUICK Norovirus IC assay is a highly sensitive and specific rapid diagnostic tool for detecting various norovirus genotypes in children with acute gastroenteritis.
May aid rapid norovirus diagnosis in hospitalized children; leaves open need for broader validation before routine adoption.
Immunochromatographic (IC) test for norovirus detection is a rapid and simple detection method. This study evaluated the sensitivity and specificity of a recent version of R-Biopharm RIDA®QUICK Norovirus IC assay for norovirus detection in fecal specimens from children hospitalized with acute gastroenteritis. Fecal specimens were tested by IC kit in comparison with gold standard reverse transcription polymerase chain reaction (RT-PCR) and real-time RT-PCR. The IC kit showed high sensitivity and specificity comparable with PCR-based methods. None of false positive and false negative was found and the assay did not cross-react with other gastroenteritis viruses. The IC assay could detect genogroup I.5 (GI.5) and a wide range of genotypes in the GII noroviruses including GII.3, GII.4, GII.6, GII.7, GII.14, GII.15, GII.21, and also newly emerging GII.17 norovirus. In conclusion, this norovirus IC kit could be an alternative choice for rapid screening or a quick diagnostic tool for norovirus detection in fecal specimens of acute gastroenteritis patients.
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Kumthip et al. (2017) conducted a cross-sectional in Acute gastroenteritis. R-Biopharm RIDA®QUICK Norovirus IC assay vs. RT-PCR and real-time RT-PCR was evaluated on Sensitivity and specificity for norovirus detection. The R-Biopharm RIDA®QUICK Norovirus IC assay demonstrated high sensitivity and specificity comparable to PCR-based methods, with zero false positives or false negatives detected.
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