Possible Addiction Transference From Cocaine Insufflation to Oral Bupropion in Bipolar Patient

OBJECTIVE: Alert for the risk of oral bupropion addiction in patients with cocaine dependence. METHODS: Single-case study. RESULTS: After a period of cocaine and alcohol abstinence, a 42-year-old patient started taking oral bupropion to relieve the symptoms of cocaine craving. He increased the bupropion dose up to 2250 mg/d without seizures. CONCLUSION: This case highlights the possibility of oral bupropion addiction after cocaine dependence. To our knowledge, it is the first case in the literature and emphasizes the risk of bupropion's misuse. Therefore, physicians should carefully examine the patient's profile before prescribing it, as well as follow appropriate measures.