Key result
Novel 8-channel telemetry system successfully enables continuous multiparameter cardiopulmonary monitoring in preclinical testing.
Why the study?
A need existed for a miniaturized, low-power, multifunctional telemetry system to continuously record electrical, mechanical, and hemodynamical data in chronic cardiovascular disease animal models.
The development of a miniaturized eight-channel telemetry system enables continuous electrical, mechanical, and hemodynamical recordings in animal models to study events leading to sudden cardiac arrest.
Enables multi-parameter monitoring in chronic animal CVD models; leaves open translation to clinical research.
We have developed an eight-channel telemetry system for studying experimental models of chronic cardiovascular disease. The system is an extension of a previous device that has been miniaturized, reduced in power consumption and provided with increased functionality. We added sensors for ventricular dimension, and coronary artery blood flow and arterial blood pressure that are suitable for use with the system. The telemetry system consists of a front end, a backpack and a host PC. The front end is a watertight stainless steel case with all sensor electronics sealed inside; it acquires dimension, flow, pressure and five cardiac electrograms from selected locations on the heart. The backpack includes a control unit, Bluetooth radio, and batteries. The control unit digitizes eight channels of data from the front end and forwards them to the host PC via Bluetooth link. The host PC has a receiving Bluetooth radio and Labview programs to store and display data. The whole system was successfully tested on the bench and in an animal model. This telemetry system will greatly enhance the ability to study events leading to spontaneous sudden cardiac arrest.
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Kong et al. (2007) studied Experimental models of chronic cardiovascular disease. Eight-channel telemetry system was evaluated. A newly developed eight-channel telemetry system for continuous electrical, mechanical, and hemodynamical recordings was successfully tested on the bench and in an animal model.
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