To study Clinical and Laboratory Characteristics and Risk Factors for Fatality in Geriatric Patients compared with Adult with Dengue Hemorrhagic Fever at tertiary hospital

Introduction: Dengue fever (DF) has been re-emerging over the last several decades.A large number of patients were adults in general and elderly individuals in particular which was in sharp contrast to the predominant pediatric patients seen in the dengue epidemics recently.Advanced age per se has been previously reported to be a high risk factor for mortality in dengue virus infection.There only few study in elderly patients, so this study was conducted to find risk factors for fatality in elderly.Aim Of Study 1.To Compare clinical and Laboratory manifestations of DHF between elderly and adults.2. To identify risk factors for fatality in the elderly population.Materials And Methods: This was retrospective study conducted in patients with DHF admitted between January 2010 to December 2012 in Dr Prabharkar's KLE Hospital and research Center Belgaum, Karnataka India, a 2000 bed multispecialty hospital.Medical records were revived and detail data was collected for 154 patients.Results: 21 elderly (age>60 years) and 132 adults (age 19-60 years) with DHF were retrospectively analyzed.Compared with adults, in elderly individuals there was no significant difference in symptoms' and signs seen.When compared with non-fatal elderly patients with DHF, a significant higher frequency in men (P _ 0.019), those with hypertension (P _ 0.018), those with dengue shock syndrome (DSS; P < 0.001), and those with acute renal failure (P < 0.021) was found in the Fatal elderly, with statically significant.Multivariate analysis showed that only DSS (odd ratio3.81,P _ 0.036) was an independent risk factor for fatality.Conclusion: There were no differences in clinical manifestations and laboratory characteristics between the elderly and younger adults with DHF.Among adults with DHF, the elderly have a higher mortality rate compared with the younger ones.DSS is an independent risk factor for fatality in elderly patients with DHF.