Diaphanous-related formin 3 (DIAPH3) is a pivotal member of the formin family and serves as a crucial regulator of actin filament assembly. As such, DIAPH3 plays an integral role in a variety of cellular processes including cytokinesis, cell migration, and intracellular transport. Given its fundamental importance in maintaining cytoskeletal dynamics, DIAPH3 is functionally associated with numerous physiological and pathological conditions, particularly cancer. In this review, we explore the structural and functional characteristics of DIAPH3 and investigate its mutational and transcriptional landscape in human cancers. By focusing on DIAPH3's role in controlling metastasis and tumor microenvironment, we aim to provide new insights into how DIAPH3 contributes to tumor development and progression. Altogether, we believe that an enhanced understanding of the DIAPH3 signalosome will facilitate more precise clinical decision-making and the development of novel therapeutics against aggressive cancers.
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Xiong et al. (2025) studied this question.
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