Key result
Death receptors of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family contribute to cell death and survival in CNS pathology, suggesting potential therapeutic value in their manipulation.
Manipulating cell death induced by TNF/NGF family death receptors may offer therapeutic strategies for neurodegenerative diseases and ischemic CNS injury.
Death receptor pathways may modulate neuronal survival in neurodegeneration; leaves open targeted therapies pending mechanistic and clinical validation.
Programmed cell death is an essential process in the development of the central nervous system (CNS) and is fundamental for the control of the final number of neurons and glial cells. Excessive cell death has been implicated in a growing number of neurodegenerative diseases, such as Alzheimer's, Parkinson's, and multiple sclerosis as well as ischemic injury. We review the contribution of death receptors of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family to cell death and survival in the context of CNS pathology, indicating the possible value of manipulating cell death induced by these receptors for the treatment of CNS diseases and injury.
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Corina Lorz (2009) conducted a review in Central nervous system pathology and neurodegenerative diseases. Death receptors of the TNF/NGF family was evaluated. Death receptors of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family contribute to cell death and survival in CNS pathology, suggesting potential therapeutic value in their manipulation.
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