Acute Hepatitis in Children in 2022 — Human Adenovirus 41?

Acute hepatitis in children is certainly not new, and it can be worrisome. Successful worldwide vaccination campaigns over the past few decades have led to demonstrable improvements in public health and well-being by reducing the incidence and consequences of two viral causes — hepatitis A and B viruses. Many other viruses, some quite commonly encountered during childhood, are hepatotropic and in a minority of patients may cause illness that can escalate in severity. In these cases, liver damage manifests as elevations in serum levels of liver enzymes, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), that can increase rapidly . . .