Key result
The ACTN3 X-homozygote genotype was associated with a greater risk of incident persistent lower extremity limitation in older women compared to R-homozygotes (HR 0.65; 95% CI 0.44-0.94).
Why the study?
Does the ACTN3 R577X polymorphism influence physical performance decline in older adults?
Population
2,519 white older adults, comprising 1,367 adults aged 70-79 years from the Health, Aging and Body…
Comparison
ACTN3 R577X polymorphism (X-homozygotes) vs R-homozygotes and heterozygotes
Design
Cohort
Follow-up
5 years
Authors
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Weak, inconsistent links to select declines; leaves open modest genetic role in sarcopenia research.
Cohort (n=2,519)
Does the ACTN3 R577X polymorphism influence physical performance decline in older adults?
Hazard Ratio: 0.65 (95% CI 0.44–0.94)
The ACTN3 R577X polymorphism does not appear to have a strong or consistent effect on skeletal muscle-related phenotypes or physical performance decline during aging.
Delmonico et al. (2008) conducted a cohort in Physical functioning decline with aging (n=2,519). ACTN3 R577X polymorphism (X-homozygotes) vs. R-homozygotes and heterozygotes was evaluated on Incident persistent lower extremity limitation (PLL) over 5 years in women (HR 0.65, 95% CI 0.44-0.94). The ACTN3 X-homozygote genotype was associated with a greater risk of incident persistent lower extremity limitation in older women compared to R-homozygotes (HR 0.65; 95% CI 0.44-0.94).
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